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NFL schedule: Week 1 odds set for Dolphins at Colts

May 23, 2025 by The Phinsider

Miami Dolphins v Indianapolis Colts
Photo by Andy Lyons/Getty Images

The Miami Dolphins will visit the Indianapolis Colts in Week 1 of the 2025 NFL season. Who do the oddsmakers think will win?

The offseason continues as the NFL calendar continues to march toward the 2025 regular season. The Miami Dolphins are closing in on the start of their organized team activities next week, with the mandatory minicamp coming in a couple more weeks. The team will then break before the start of training camp in July.

This week, the Dolphins made a roster move to add a fourth quarterback to the roster, announced their preseason schedule, and looked toward potential veteran cornerback additions. It has been a busy week, and there will be plenty of changes between now and Sunday, September 7, when the Dolphins kickoff against the Indianapolis Colts to start the season. Even with questions still be answered, the oddsmakers at FanDuel have released and updated Week 1 odds for the entire NFL schedule. How do they think the Dolphins at Colts game will play out?

According to the latest odds, they are giving the Colts a slight advantage in the game – but slight is the key word. The line is only half the normal homefield advantage spread, with the Colts listed at just -1.5 on the latest line. According to their stats, nearly 90 percent of the money is coming in on the Dolphins right now, with seven-in-ten bets aligning with Miami covering the spread.

The Dolphins are -120 on the moneyline for the straight-up win, with the Colts -102. The point total seems relatively low at just 45.5 points.

Will the Dolphins win the game? Will it be a close game as the 1.5-point spread seems to suggest?

Taking a look around the AFC East, the New York Jets, set to host the Pittsburgh Steelers, are three-point home underdogs; the New England Patriots are 2.5-point favorites at home against the Las Vegas Raiders; and the Buffalo Bills, hosting the Baltimore Ravens, are 1.5-point favorites.

Do you agree with these lines? Which bet do you think is the best to make? How will Week 1 play out in the AFC East? Head to the comments to let us know your thoughts.

Filed Under: Dolphins

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