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Week 16 Early Afternoon Games
Indianapolis Colts (8-6) 2nd AFC South @ Atlanta Falcons (6-8) 3rd NFC South
- Where: Mercedes-Benz Stadium, Atlanta, Georgia
- When: 1:00 PM EST
- TV: FOX
- Line: Falcons -2.5
- Over/Under: 45
Seattle Seahawks (7-7) 3rd NFC West @ Tennessee Titans (5-9) 4th AFC South
- Where: Nissan Stadium, Nashville, Tennessee
- When: 1:00 PM EST
- TV: CBS
- Line: Seahawks -3.5
- Over/Under: 41.5
Detriot Lions (10-4) 1st NFC North @ Minnesota Vikings (7-7) 2nd NFC North
- Where: U.S. Bank Stadium, Minneapolis, Minnesota
- When: 1:00 PM EST
- TV: FOX
- Line: Lions -3
- Over/Under: 47
Washington Commanders (4-10) 4th NFC East @ New York Jets (5-9) 3rd AFC East
- Where: MetLife Stadium, East Rutheford, New Jersey
- When: 1:00 PM EST
- TV: CBS
- Line: Jets -3
- Over/Under: 37
Green Bay Packers (6-8) 3rd NFC North @ Carolina Panthers (2-12) 4th NFC South
- Where: Bank Of America Stadium, Charlotte, North Carolina
- When: 1:00 PM EST
- TV: FOX
- Line: Packers -4.5
- Over/Under: 37.5
Cleveland Browns (9-5) 2nd AFC North @ Houston Texans (8-6) 3rd AFC South
- Where: NRG Stadium, Houston, Texas
- When: 1:00 PM EST
- TV: CBS
- Line: Browns -3
- Over/Under: 40